Sucker Punch's newest PS3 exclusive, inFamous, made it's retail debut two weeks ago on May 26. On top of a surprisingly decent marketing campaign, which included a trailer prior to the summer blockbuster, Terminator Salvation, and several TV ads, the game sold 176,000 copies it's first week on the market. InFamous has set the bar for new IPs that are exclusive to the PS3 in the US, making a stronger first week debut than any other new IP before it. Following number come courtesy of VGChartz and NPD.
-InFamous(May, 2009) - 176,000 in it's first week

-Resistance(Nov.,2006) - 42K first week
-Motorstorm(March, 2007) - 107K first week
-Warhawk(August, 2007) - 70K first week(not including downloads)
-Lair(August, 2007) - 69K first week
-Heavenly Sword(Sept., 2007) - 75K first week, 130K first month
-Uncharted(Nov., 2007) - 32K first week, 117K first month sales(ed. note: WTF?)
-Haze(May, 2008) - 91K first week, 102K first month
-LittleBigPlanet(October, 2008) - 110K first week